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KMID : 0624620210540060285
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BMB Reports
2021 Volume.54 No. 6 p.285 ~ p.294
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A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
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Cha Bok-Sik
Moon Sung-Jin
Kim Wan-Tae
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Abstract
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The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.
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KEYWORD
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Hippo signaling pathway, Lymphatic endothelial cells (LECs), Lymphatic vascular development, PROX1, TAZ, VEGF-C/VEGFR3, YAP
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